Substituents at the C3′ and C3′N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel

We tested the role of substituents at the C3′ and C3′N positions of the taxane molecule to identify taxane derivatives capable of overcoming acquired resistance to paclitaxel. Paclitaxel-resistant sublines SK-BR-3/PacR and MCF-7/PacR as well as the original paclitaxel-sensitive breast cancer cell li...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Jelínek, Michael, Balušíková, Kamila, Daniel, Petr, Němcová-Fürstová, Vlasta, Kirubakaran, Palani, Jaček, Martin, Wei, Longfei, Wang, Xin, Vondrášek, Jiří, Ojima, Iwao, Kovář, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937276/
https://ncbi.nlm.nih.gov/pubmed/29625142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2018.04.002
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