Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1

Inositol hexakisphosphate kinase-1 (IP6K1) is required for male fertility, but the underlying mechanisms have been elusive. Here, we report that IP6K1 is required for multiple aspects of male germ cell development. This development requires selective interactions between germ cells and Sertoli cells...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Fu, Chenglai, Rojas, Tomas, Chin, Alfred C., Cheng, Weiwei, Bernstein, Isaac A., Albacarys, Lauren K., Wright, William W., Snyder, Solomon H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935691/
https://ncbi.nlm.nih.gov/pubmed/29728588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25468-8
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