Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase

Inositol hexakisphosphate kinase 1 (IP6K1), which generates 5-diphosphoinositol pentakisphosphate (5-IP7), physiologically mediates numerous functions. We report that IP6K1 deletion leads to brain malformation and abnormalities of neuronal migration. IP6K1 physiologically associates with α-actinin a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Fu, Chenglai, Xu, Jing, Cheng, Weiwei, Rojas, Tomas, Chin, Alfred C., Snowman, Adele M., Harraz, Maged M., Snyder, Solomon H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338408/
https://ncbi.nlm.nih.gov/pubmed/28154132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700165114
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