Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2

The inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase Akt signaling, and its aberrant increase in cells has been implicated in apoptosis and insulin resistance. Inositol hexakisphosphate kinase-2 (IP6K2), one of the major inositol pyrophosphate synthesizin...

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Hauptverfasser: Chakraborty, Anutosh, Werner, J. Kent, Koldobskiy, Michael A., Mustafa, Asif K., Juluri, Krishna R., Pietropaoli, Joseph, Snowman, Adele M., Snyder, Solomon H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038742/
https://ncbi.nlm.nih.gov/pubmed/21262846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019381108
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