Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation

RATIONALE: Inositol polyphosphate multikinase (IPMK) and its major product inositol pentakisphosphate (IP5) regulate a variety of cellular functions, but their role in vascular biology remains unexplored. OBJECTIVE: We have investigated the role of IPMK in regulating angiogenesis. METHODS AND RESULT...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Fu, Chenglai, Tyagi, Richa, Chin, Alfred C., Rojas, Tomas, Li, Ruo-Jing, Guha, Prasun, Bernstein, Isaac A., Rao, Feng, Xu, Risheng, Cha, Jiyoung Y., Xu, Jing, Snowman, Adele M., Semenza, Gregg L., Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805644/
https://ncbi.nlm.nih.gov/pubmed/29279301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311983
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