Huntington’s disease: Neural dysfunction linked to inositol polyphosphate multikinase

Huntington’s disease (HD) is a progressive neurodegenerative disease caused by a glutamine repeat expansion in mutant huntingtin (mHtt). Despite the known genetic cause of HD, the pathophysiology of this disease remains to be elucidated. Inositol polyphosphate multikinase (IPMK) is an enzyme that di...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Ahmed, Ishrat, Sbodio, Juan I., Harraz, Maged M., Tyagi, Richa, Grima, Jonathan C., Albacarys, Lauren K., Hubbi, Maimon E., Xu, Risheng, Kim, Seyun, Paul, Bindu D., Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534278/
https://ncbi.nlm.nih.gov/pubmed/26195796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511810112
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