Huntington’s disease: Neural dysfunction linked to inositol polyphosphate multikinase

Huntington’s disease (HD) is a progressive neurodegenerative disease caused by a glutamine repeat expansion in mutant huntingtin (mHtt). Despite the known genetic cause of HD, the pathophysiology of this disease remains to be elucidated. Inositol polyphosphate multikinase (IPMK) is an enzyme that di...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ahmed, Ishrat, Sbodio, Juan I., Harraz, Maged M., Tyagi, Richa, Grima, Jonathan C., Albacarys, Lauren K., Hubbi, Maimon E., Xu, Risheng, Kim, Seyun, Paul, Bindu D., Snyder, Solomon H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534278/
https://ncbi.nlm.nih.gov/pubmed/26195796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511810112
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