IRF8 regulates transcription of Naips for NLRC4 inflammasome activation

Inflammasome activation is critical for host defense against various microbial infections. Activation of the NLRC4 inflammasome requires detection of flagellin or type III secretion system (T3SS) components by NLR family apoptosis inhibitory proteins (NAIPs); yet how this pathway is regulated is unk...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Karki, Rajendra, Lee, Ein, Place, David, Samir, Parimal, Mavuluri, Jayadev, Sharma, Bhesh Raj, Balakrishnan, Arjun, Subbarao Malireddi, R. K., Geiger, Rechel, Zhu, Qifan, Neale, Geoffrey, Kanneganti, Thirumala-Devi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935577/
https://ncbi.nlm.nih.gov/pubmed/29576451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.055
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