IRF8 regulates transcription of Naips for NLRC4 inflammasome activation

Inflammasome activation is critical for host defense against various microbial infections. Activation of the NLRC4 inflammasome requires detection of flagellin or type III secretion system (T3SS) components by NLR family apoptosis inhibitory proteins (NAIPs); yet how this pathway is regulated is unk...

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Bibliographic Details
Published in:Cell
Main Authors: Karki, Rajendra, Lee, Ein, Place, David, Samir, Parimal, Mavuluri, Jayadev, Sharma, Bhesh Raj, Balakrishnan, Arjun, Subbarao Malireddi, R. K., Geiger, Rechel, Zhu, Qifan, Neale, Geoffrey, Kanneganti, Thirumala-Devi
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935577/
https://ncbi.nlm.nih.gov/pubmed/29576451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.055
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