Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis

OBJECTIVES: The citrullinating enzyme peptidylarginine deminase type 4 (PAD4) is the target of a polyclonal group of autoantibodies in patients with rheumatoid arthritis (RA). A subgroup of such antibodies, initially identified by cross-reactivity with PAD3, is strongly associated with progression o...

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Udgivet i:Ann Rheum Dis
Main Authors: Shi, Jing, Darrah, Erika, Sims, Gary P., Mustelin, Tomas, Sampson, Kevon, Konig, Maximilian F., Bingham, Clifton O., Rosen, Antony, Andrade, Felipe
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935255/
https://ncbi.nlm.nih.gov/pubmed/29070531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2017-211489
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