Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis

Objective: Peptidylarginine deiminases (PAD) 2 and 4 are key enzymes in rheumatoid arthritis (RA) pathogenesis due to their ability to generate the protein targets of anti-citrullinated protein antibodies (ACPA). Anti-PAD4 antibodies that cross-react with PAD3 (anti-PAD3/4) have been identified and...

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Опубликовано в: :Front Immunol
Главные авторы: Darrah, Erika, Giles, Jon T., Davis, Ryan L., Naik, Pooja, Wang, Hong, Konig, Maximilian F., Cappelli, Laura C., Bingham, Clifton O., Danoff, Sonye K., Andrade, Felipe
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255931/
https://ncbi.nlm.nih.gov/pubmed/30515171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02696
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