Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis

OBJECTIVES: The citrullinating enzyme peptidylarginine deminase type 4 (PAD4) is the target of a polyclonal group of autoantibodies in patients with rheumatoid arthritis (RA). A subgroup of such antibodies, initially identified by cross-reactivity with PAD3, is strongly associated with progression o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Shi, Jing, Darrah, Erika, Sims, Gary P., Mustelin, Tomas, Sampson, Kevon, Konig, Maximilian F., Bingham, Clifton O., Rosen, Antony, Andrade, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935255/
https://ncbi.nlm.nih.gov/pubmed/29070531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2017-211489
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados