Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus

CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a defect in early double-strand break (DSB) repair via h...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Zhou, Jia, Li, Jiaqi, Serafim, Rodolfo B, Ketchum, Steven, Ferreira, Catarina G, Liu, Jessica C, Coe, Kathryn A, Price, Brendan D, Yusufzai, Timur
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934646/
https://ncbi.nlm.nih.gov/pubmed/29529298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky128
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