Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus

CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a defect in early double-strand break (DSB) repair via h...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zhou, Jia, Li, Jiaqi, Serafim, Rodolfo B, Ketchum, Steven, Ferreira, Catarina G, Liu, Jessica C, Coe, Kathryn A, Price, Brendan D, Yusufzai, Timur
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934646/
https://ncbi.nlm.nih.gov/pubmed/29529298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky128
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