Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus

CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a defect in early double-strand break (DSB) repair via h...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nucleic Acids Res
मुख्य लेखकों: Zhou, Jia, Li, Jiaqi, Serafim, Rodolfo B, Ketchum, Steven, Ferreira, Catarina G, Liu, Jessica C, Coe, Kathryn A, Price, Brendan D, Yusufzai, Timur
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2018
विषय:
Gene regulation, Chromatin and Epigenetics
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934646/
https://ncbi.nlm.nih.gov/pubmed/29529298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky128
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