Orally available soluble epoxide hydrolase/phosphodiesterase 4 dual inhibitor treats inflammatory pain

Inspired by previously discovered enhanced analgesic efficacy between soluble epoxide hydrolase (sEH) and phosphodiesterase 4 (PDE4) inhibitors, we designed, synthesized and characterized 21 novel sEH/PDE4 dual inhibitors. The best of these displayed good efficacy in in vitro assays. Further pharmac...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Blöcher, René, Wagner, Karen M., Gopireddy, Raghavender R., Harris, Todd R., Wu, Hao, Barnych, Bogdan, Hwang, Sung Hee, Xiang, Yang K., Proschak, Ewgenij, Morisseau, Christophe, Hammock, Bruce D.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933862/
https://ncbi.nlm.nih.gov/pubmed/29614224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01804
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