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Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors. Although compounds acting against CLKs have been described, only a few show selectivity against dual-specificity tyrosine phosp...

תיאור מלא

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מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Walter, Anne, Chaikuad, Apirat, Helmer, Renate, Loaëc, Nadège, Preu, Lutz, Ott, Ingo, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933782/
https://ncbi.nlm.nih.gov/pubmed/29723265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196761
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