7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a “Cut and Glue” Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors

Although overexpression and hyperactivity of protein kinases are causative for a wide range of human cancers, protein kinase inhibitors currently approved as cancer drugs address only a limited number of these enzymes. To identify new chemotypes addressing alternative protein kinases, the basic stru...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Karatas, Mehmet, Chaikuad, Apirat, Berger, Bianca, Kubbutat, Michael H. G., Totzke, Frank, Knapp, Stefan, Kunick, Conrad
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998669/
https://ncbi.nlm.nih.gov/pubmed/33799460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26061611
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