Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance

According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols. Using a novel fluorescent intracellular nitric oxide (NO) pr...

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Udgivet i:Mol Pharmacol
Main Authors: Opelt, Marissa, Wölkart, Gerald, Eroglu, Emrah, Waldeck-Weiermair, Markus, Malli, Roland, Graier, Wolfgang F., Kollau, Alexander, Fassett, John T., Schrammel, Astrid, Mayer, Bernd, Gorren, Antonius C. F.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933520/
https://ncbi.nlm.nih.gov/pubmed/29358221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110783
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