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Aldehyde dehydrogenase-independent bioactivation of nitroglycerin in porcine and bovine blood vessels
The vascular bioactivation of the antianginal drug nitroglycerin (GTN), yielding 1,2-glycerol dinitrate and nitric oxide or a related activator of soluble guanylate cyclase, is catalyzed by aldehyde dehydrogenase-2 (ALDH2) in rodent and human blood vessels. The essential role of ALDH2 has been confi...
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| Yayımlandı: | Biochem Pharmacol |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier Science
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4321882/ https://ncbi.nlm.nih.gov/pubmed/25576686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.12.021 |
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