Aldehyde dehydrogenase-independent bioactivation of nitroglycerin in porcine and bovine blood vessels

The vascular bioactivation of the antianginal drug nitroglycerin (GTN), yielding 1,2-glycerol dinitrate and nitric oxide or a related activator of soluble guanylate cyclase, is catalyzed by aldehyde dehydrogenase-2 (ALDH2) in rodent and human blood vessels. The essential role of ALDH2 has been confi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem Pharmacol
Main Authors: Neubauer, Regina, Wölkart, Gerald, Opelt, Marissa, Schwarzenegger, Christine, Hofinger, Marielies, Neubauer, Andrea, Kollau, Alexander, Schmidt, Kurt, Schrammel, Astrid, Mayer, Bernd
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Science 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321882/
https://ncbi.nlm.nih.gov/pubmed/25576686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.12.021
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