Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases

Metabolism of nitroglycerin (GTN) to 1,2-glycerol dinitrate (GDN) and nitrite by mitochondrial aldehyde dehydrogenase (ALDH2) is essentially involved in GTN bioactivation resulting in cyclic GMP-mediated vascular relaxation. The link between nitrite formation and activation of soluble guanylate cycl...

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Main Authors: Beretta, Matteo, Gruber, Karl, Kollau, Alexander, Russwurm, Michael, Koesling, Doris, Goessler, Walter, Keung, Wing Ming, Schmidt, Kurt, Mayer, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440601/
https://ncbi.nlm.nih.gov/pubmed/18450747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801182200
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