Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2

Mitochondrial aldehyde dehydrogenase-2 (ALDH2) plays an essential role in nitroglycerin (GTN) bioactivation, resulting in formation of NO or a related activator of soluble guanylate cyclase. ALDH2 denitrates GTN to 1,2-glyceryl dinitrate and nitrite but also catalyzes reduction of GTN to NO. To eluc...

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Detalhes bibliográficos
Main Authors: Wenzl, M. Verena, Beretta, Matteo, Gorren, Antonius C. F., Zeller, Andreas, Baral, Pravas K., Gruber, Karl, Russwurm, Michael, Koesling, Doris, Schmidt, Kurt, Mayer, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740413/
https://ncbi.nlm.nih.gov/pubmed/19506075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005652
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