Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide

Vascular relaxation to GTN (nitroglycerin) and other antianginal nitrovasodilators requires bioactivation of the drugs to NO or a related activator of sGC (soluble guanylate cyclase). Conversion of GTN into 1,2-GDN (1,2-glycerol dinitrate) and nitrite by mitochondrial ALDH2 (aldehyde dehydrogenase 2...

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Main Authors: Kollau, Alexander, Hofer, Alexandra, Russwurm, Michael, Koesling, Doris, Keung, Wing Ming, Schmidt, Kurt, Brunner, Friedrich, Mayer, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2005
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134753/
https://ncbi.nlm.nih.gov/pubmed/15377279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041354
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