Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide

Vascular relaxation to GTN (nitroglycerin) and other antianginal nitrovasodilators requires bioactivation of the drugs to NO or a related activator of sGC (soluble guanylate cyclase). Conversion of GTN into 1,2-GDN (1,2-glycerol dinitrate) and nitrite by mitochondrial ALDH2 (aldehyde dehydrogenase 2...

Full description

Saved in:
Bibliographic Details
Main Authors: Kollau, Alexander, Hofer, Alexandra, Russwurm, Michael, Koesling, Doris, Keung, Wing Ming, Schmidt, Kurt, Brunner, Friedrich, Mayer, Bernd
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134753/
https://ncbi.nlm.nih.gov/pubmed/15377279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041354
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items