Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat

Belonging to the class of so-called soluble guanylate cyclase (sGC) activators, cinaciguat and BAY 60-2770 are interesting therapeutic tools for the treatment of various cardiovascular pathologies. The drugs are supposed to preferentially stimulate oxidized or heme-depleted, but not native sGC. Sinc...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Kollau, Alexander, Opelt, Marissa, Wölkart, Gerald, Gorren, Antonius C. F., Russwurm, Michael, Koesling, Doris, Mayer, Bernd, Schrammel, Astrid
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916872/
https://ncbi.nlm.nih.gov/pubmed/29138269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109918
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