Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein

Ligation of OX40 (CD134, TNFRSF4) on activated T cells by its natural ligand (OX40L, CD252, TNFSF4) enhances cellular survival, proliferation, and effector functions such as cytokine release and cellular cytotoxicity. We engineered a recombinant human OX40L IgG4P Fc fusion protein termed MEDI6383 th...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Oberst, Michael D., Augé, Catherine, Morris, Chad, Kentner, Stacy, Mulgrew, Kathy, McGlinchey, Kelly, Hair, James, Hanabuchi, Shino, Du, Qun, Damschroder, Melissa, Feng, Hui, Eck, Steven, Buss, Nicholas, de Haan, Lolke, Pierce, Andrew J., Park, Haesun, Sylwester, Andrew, Axthelm, Michael K., Picker, Louis, Morris, Nicholas P., Weinberg, Andrew, Hammond, Scott A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932227/
https://ncbi.nlm.nih.gov/pubmed/29545330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0200
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