MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effector T cells and inhibiting regulatory T cells. Her...

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Publicado en:Oncoimmunology
Autores principales: Tigue, Natalie J., Bamber, Lisa, Andrews, John, Ireland, Samantha, Hair, James, Carter, Edward, Sridharan, Sudharsan, Jovanović, Jelena, Rees, D. Gareth, Springall, Jeremy S., Solier, Emilie, Li, Yi-Ming, Chodorge, Matthieu, Perez-Martinez, David, Higazi, Daniel R., Oberst, Michael, Kennedy, Maureen, Black, Chelsea M., Yan, Li, Schwickart, Martin, Maguire, Shaun, Cann, Jennifer A., de Haan, Lolke, Young, Lesley L., Vaughan, Tristan, Wilkinson, Robert W., Stewart, Ross
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384396/
https://ncbi.nlm.nih.gov/pubmed/28405505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1280645
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