Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein

Ligation of OX40 (CD134, TNFRSF4) on activated T cells by its natural ligand (OX40L, CD252, TNFSF4) enhances cellular survival, proliferation, and effector functions such as cytokine release and cellular cytotoxicity. We engineered a recombinant human OX40L IgG4P Fc fusion protein termed MEDI6383 th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Oberst, Michael D., Augé, Catherine, Morris, Chad, Kentner, Stacy, Mulgrew, Kathy, McGlinchey, Kelly, Hair, James, Hanabuchi, Shino, Du, Qun, Damschroder, Melissa, Feng, Hui, Eck, Steven, Buss, Nicholas, de Haan, Lolke, Pierce, Andrew J., Park, Haesun, Sylwester, Andrew, Axthelm, Michael K., Picker, Louis, Morris, Nicholas P., Weinberg, Andrew, Hammond, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932227/
https://ncbi.nlm.nih.gov/pubmed/29545330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados