Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice

An urgent need exists for the development of more efficacious molecular strategies targeting non-melanoma skin cancer (NMSC), the most common malignancy worldwide. Inflammatory signaling downstream of Toll-like receptor 4 (TLR4) has been implicated in several forms of tumorigenesis, yet its role in...

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Pubblicato in:Cancer Prev Res (Phila)
Autori principali: Blohm-Mangone, Karen, Burkett, Nichole B., Tahsin, Shekha, Myrdal, Paul B., Aodah, Alhassan, Ho, Brenda, Janda, Jaroslav, McComas, Michelle, Saboda, Kathylynn, Roe, Denise J., Dong, Zigang, Bode, Ann M., Petricoin, Emanuel F., Calvert, Valerie S., Curiel-Lewandrowski, Clara, Alberts, David S., Wondrak, Georg T., Dickinson, Sally E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932085/
https://ncbi.nlm.nih.gov/pubmed/29437671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-17-0349
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