Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin

The PI3Kinase/Akt/mTOR pathway has important roles in cancer development for multiple tumor types, including UV-induced non-melanoma skin cancer. Immunosuppressed populations are at increased risk of aggressive cutaneous squamous cell carcinoma (SCC). Individuals who are treated with rapamycin, (sir...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Dickinson, Sally E., Janda, Jaroslav, Criswell, Jane, Blohm-Mangone, Karen, Olson, Erik R., Liu, Zhonglin, Barber, Christie, Petricoin, Emanuel F., Calvert, Valerie S., Einspahr, Janine, Dickinson, Jesse E., Stratton, Steven P., Curiel-Lewandrowski, Clara, Saboda, Kathylynn, Hu, Chengcheng, Bode, Ann M., Dong, Zigang, Alberts, David S., Bowden, G. Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777684/
https://ncbi.nlm.nih.gov/pubmed/26801880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-15-0419
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