Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice

An urgent need exists for the development of more efficacious molecular strategies targeting non-melanoma skin cancer (NMSC), the most common malignancy worldwide. Inflammatory signaling downstream of Toll-like receptor 4 (TLR4) has been implicated in several forms of tumorigenesis, yet its role in...

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Publicat a:Cancer Prev Res (Phila)
Autors principals: Blohm-Mangone, Karen, Burkett, Nichole B., Tahsin, Shekha, Myrdal, Paul B., Aodah, Alhassan, Ho, Brenda, Janda, Jaroslav, McComas, Michelle, Saboda, Kathylynn, Roe, Denise J., Dong, Zigang, Bode, Ann M., Petricoin, Emanuel F., Calvert, Valerie S., Curiel-Lewandrowski, Clara, Alberts, David S., Wondrak, Georg T., Dickinson, Sally E.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932085/
https://ncbi.nlm.nih.gov/pubmed/29437671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-17-0349
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