Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD(8) is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple p...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Murillo-Garzón, Virginia, Gorroño-Etxebarria, Irantzu, Åkerfelt, Malin, Puustinen, Mikael Christer, Sistonen, Lea, Nees, Matthias, Carton, James, Waxman, Jonathan, Kypta, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931552/
https://ncbi.nlm.nih.gov/pubmed/29717114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04042-w
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky