Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD(8) is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple p...

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Udgivet i:Nat Commun
Main Authors: Murillo-Garzón, Virginia, Gorroño-Etxebarria, Irantzu, Åkerfelt, Malin, Puustinen, Mikael Christer, Sistonen, Lea, Nees, Matthias, Carton, James, Waxman, Jonathan, Kypta, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931552/
https://ncbi.nlm.nih.gov/pubmed/29717114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04042-w
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