Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1

Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is downregulated in prostate cancer and upregulated in the stroma in benign prostatic hyperplasia, but the function of stromal Dkk-3...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Al Shareef, Zainab, Kardooni, Hoda, Murillo-Garzón, Virginia, Domenici, Giacomo, Stylianakis, Emmanouil, Steel, Jennifer H., Rabano, Miriam, Gorroño-Etxebarria, Irantzu, Zabalza, Ignacio, Vivanco, Maria dM, Waxman, Jonathan, Kypta, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160402/
https://ncbi.nlm.nih.gov/pubmed/29858602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0294-0
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