PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells to induce immune tolerance.(1,2) Tumor cells frequently overexpress the ligand for PD-1, programmed cell death ligand 1 (PD-L1), facilitating escape from the immune system.(3,4) Monoclona...

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Bibliografiska uppgifter
I publikationen:Nature
Huvudupphovsmän: Gordon, Sydney R., Maute, Roy L., Dulken, Ben W., Hutter, Gregor, George, Benson M., McCracken, Melissa N., Gupta, Rohit, Tsai, Jonathan M., Sinha, Rahul, Corey, Daniel, Ring, Aaron M., Connolly, Andrew J., Weissman, Irving L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931375/
https://ncbi.nlm.nih.gov/pubmed/28514441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22396
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