PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells to induce immune tolerance.(1,2) Tumor cells frequently overexpress the ligand for PD-1, programmed cell death ligand 1 (PD-L1), facilitating escape from the immune system.(3,4) Monoclona...

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Publicado no:Nature
Main Authors: Gordon, Sydney R., Maute, Roy L., Dulken, Ben W., Hutter, Gregor, George, Benson M., McCracken, Melissa N., Gupta, Rohit, Tsai, Jonathan M., Sinha, Rahul, Corey, Daniel, Ring, Aaron M., Connolly, Andrew J., Weissman, Irving L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931375/
https://ncbi.nlm.nih.gov/pubmed/28514441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22396
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