Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model

T cell receptor (TCR) T cell therapy is a promising cancer treatment modality. However, its successful development for epithelial cancers may depend on the identification of high-avidity TCRs directed against tumor-restricted target antigens. The human papillomavirus (HPV) E7 antigen is an attractiv...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jin, Benjamin Y., Campbell, Tracy E., Draper, Lindsey M., Stevanović, Sanja, Weissbrich, Bianca, Yu, Zhiya, Restifo, Nicholas P., Rosenberg, Steven A., Trimble, Cornelia L., Hinrichs, Christian S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931134/
https://ncbi.nlm.nih.gov/pubmed/29669936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99488
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