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Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity

Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell Proteomics
Hoofdauteurs: Li, Zhihuan, Lai, Zon Weng, Christiano, Romain, Gazos-Lopes, Felipe, Walther, Tobias C., Farese, Robert V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930403/
https://ncbi.nlm.nih.gov/pubmed/29414761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000560
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