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Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform
CRISPR/Cas9 activation (CRISPRa) systems have enabled genetic screens in cultured cells lines to discover and characterize drivers and inhibitors of cancer cell growth. We adapted this system for use in vivo to assess whether modulating endogenous gene expression levels can result in functional outc...
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| Publicado en: | Hepatology |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5930141/ https://ncbi.nlm.nih.gov/pubmed/29091290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29626 |
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