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Structural basis for substrate helix remodeling and cleavage loop activation in the Varkud satellite ribozyme

The Varkud satellite (VS) ribozyme catalyzes site-specific RNA cleavage and ligation reactions. Recognition of the substrate involves a kissing loop interaction between the substrate and the catalytic domain of the ribozyme resulting in a rearrangement of the substrate helix register into a so-calle...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: DasGupta, Saurja, Suslov, Nikolai B., Piccirilli, Joseph A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929484/
https://ncbi.nlm.nih.gov/pubmed/28625058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b03655
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