Inhibition of vaccinia virus replication by nitazoxanide

Nitazoxanide (NTZ) is an FDA-approved anti-protozoal drug that inhibits several bacteria and viruses as well. However, its effect on poxviruses is unknown. Therefore, we investigated the impact of NTZ on vaccinia virus (VACV). We found that NTZ inhibits VACV production with an EC(50) of ~2μM, a pote...

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Bibliographic Details
Published in:Virology
Main Authors: Hickson, Sarah E., Margineantu, Daciana, Hockenbery, David M., Simon, Julian A., Geballe, Adam P.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929478/
https://ncbi.nlm.nih.gov/pubmed/29625403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.03.023
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