Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis

Inactivation of NF2/Merlin causes the autosomal dominant cancer predisposition syndrome Familial Neurofibromatosis Type 2 (NF2) and contributes to the development of malignant pleural mesothelioma (MPM). In order to develop a targeted therapy for NF2-mutant tumors, we have exploited the recent reali...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Cooper, Jonathan, Xu, Qingwen, Zhou, Lu, Pavlovic, Milica, Ojeda, Virginia, Moulick, Kamalika, de Stanchina, Elisa, Poirier, J.T., Zauderer, Marjorie, Rudin, Charles M., Karajannis, Matthias A., Hanemann, C.O., Giancotti, Filippo G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929164/
https://ncbi.nlm.nih.gov/pubmed/28468780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0821
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