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Unrestrained p38 MAPK Activation in Dusp1/4 Double Null Mice Induces Cardiomyopathy

RATIONALE: Mitogen-activated protein kinases (MAPKs) are activated in the heart by disease- and stress-inducing stimuli where they participate in hypertrophy, remodeling, contractility, and heart failure. A family of dual-specificity phosphatases (DUSPs) directly inactivates each of the MAPK termina...

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Bibliografske podrobnosti
izdano v:Circ Res
Main Authors: Auger-Messier, Mannix, Accornero, Federica, Goonasekera, Sanjeewa A., Bueno, Orlando F., Lorenz, John N., van Berlo, Jop H., Willette, Robert N., Molkentin, Jeffery D.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929162/
https://ncbi.nlm.nih.gov/pubmed/22993413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.272963
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