DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility

The strength and duration of mitogen-activated protein kinase signaling is regulated through phosphorylation and dephosphorylation by dedicated dual-specificity kinases and phosphatases, respectively. Here we investigated the physiological role that extracellular signal-regulated kinases 1/2 (ERK1/2...

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Bibliografiset tiedot
Päätekijät: Maillet, Marjorie, Purcell, Nicole H., Sargent, Michelle A., York, Allen J., Bueno, Orlando F., Molkentin, Jeffery D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2008
Aiheet:
Mechanisms of Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576531/
https://ncbi.nlm.nih.gov/pubmed/18753132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806085200
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