B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex

GARP, a cell surface docking receptor for binding and activating latent TGF-β, is highly expressed by platelets and activated Tregs. While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases are unknown. Although B cells do not express GA...

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Udgivet i:JCI Insight
Main Authors: Wallace, Caroline H., Wu, Bill X., Salem, Mohammad, Ansa-Addo, Ephraim A., Metelli, Alessandra, Sun, Shaoli, Gilkeson, Gary, Shlomchik, Mark J., Liu, Bei, Li, Zihai
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928869/
https://ncbi.nlm.nih.gov/pubmed/29618665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99863
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