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Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity

Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD(+)-dependent oxidation of α-aminoadipate semialdehyde to α-aminoadipate. Structures of ALDH7A1 reveal the C-terminus is a gate that opens and closes in response to the binding of α-aminoadipate. In the clo...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Korasick, David A., Wyatt, Jesse W., Luo, Min, Laciak, Adrian R., Ruddraraju, Kasi, Gates, Kent S., Henzl, Michael T., Tanner, John J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928510/
https://ncbi.nlm.nih.gov/pubmed/29045138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00803
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