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Synthesis of thiophene based optical ligands that selectively detect tau pathology in Alzheimer’s disease

The accumulation of protein aggregates is associated with many devastating neurodegenerative diseases and the development of molecular ligands able to detect these pathological hallmarks is essential. Here, we report the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzot...

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Dettagli Bibliografici
Pubblicato in:Chemistry
Autori principali: Shirani, Hamid, Appelqvist, Hanna, Bäck, Marcus, Klingstedt, Therése, Cairns, Nigel J., Nilsson, K. Peter R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928317/
https://ncbi.nlm.nih.gov/pubmed/28926133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201703846
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