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Pentameric Thiophene-Based Ligands that Spectrally Discriminate Amyloid-β and Tau Aggregates Display Distinct Solvatochromism and Viscosity-Induced Spectral Shifts

A wide range of neurodegenerative diseases are characterized by the deposition of multiple protein aggregates. Ligands for molecular characterization and discrimination of these pathological hallmarks are thus important for understanding their potential role in pathogenesis as well as for clinical d...

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Publicat a:Chemistry
Autors principals: Simon, Rozalyn A, Shirani, Hamid, Åslund, K O Andreas, Bäck, Marcus, Haroutunian, Vahram, Gandy, Sam, Nilsson, K Peter R
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221846/
https://ncbi.nlm.nih.gov/pubmed/25111601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201402890
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