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Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

Merely touching the pancreas can lead to premature zymogen activation and pancreatitis but the mechanism is not completely understood. Here we demonstrate that pancreatic acinar cells express the mechanoreceptor Piezo1 and application of pressure within the gland produces pancreatitis. To determine...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Romac, Joelle M.-J., Shahid, Rafiq A., Swain, Sandip M., Vigna, Steven R., Liddle, Rodger A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928090/
https://ncbi.nlm.nih.gov/pubmed/29712913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04194-9
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