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Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

Merely touching the pancreas can lead to premature zymogen activation and pancreatitis but the mechanism is not completely understood. Here we demonstrate that pancreatic acinar cells express the mechanoreceptor Piezo1 and application of pressure within the gland produces pancreatitis. To determine...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Romac, Joelle M.-J., Shahid, Rafiq A., Swain, Sandip M., Vigna, Steven R., Liddle, Rodger A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928090/
https://ncbi.nlm.nih.gov/pubmed/29712913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04194-9
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