TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and nec...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Swain, Sandip M., Romac, Joelle M.-J., Shahid, Rafiq A., Pandol, Stephen J., Liedtke, Wolfgang, Vigna, Steven R., Liddle, Rodger A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190979/
https://ncbi.nlm.nih.gov/pubmed/31999644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134111
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