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TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation
Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and nec...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7190979/ https://ncbi.nlm.nih.gov/pubmed/31999644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134111 |
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