Immobilized fibrinogen activates human platelets through glycoprotein VI

Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon platelet adhesion to fibrinogen. Full spreading of human platelets on fibrinogen was aboli...

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Pubblicato in:Haematologica
Autori principali: Mangin, Pierre H, Onselaer, Marie-Blanche, Receveur, Nicolas, Le Lay, Nicolas, Hardy, Alexander T, Wilson, Clare, Sanchez, Ximena, Loyau, Stéphane, Dupuis, Arnaud, Babar, Amir K, Miller, Jeanette LC, Philippou, Helen, Hughes, Craig E, Herr, Andrew B, Ariëns, Robert AS, Mezzano, Diego, Jandrot-Perrus, Martine, Gachet, Christian, Watson, Steve P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927996/
https://ncbi.nlm.nih.gov/pubmed/29472360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.182972
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