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Immobilized fibrinogen activates human platelets through glycoprotein VI

Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon platelet adhesion to fibrinogen. Full spreading of human platelets on fibrinogen was aboli...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Haematologica
Hauptverfasser: Mangin, Pierre H, Onselaer, Marie-Blanche, Receveur, Nicolas, Le Lay, Nicolas, Hardy, Alexander T, Wilson, Clare, Sanchez, Ximena, Loyau, Stéphane, Dupuis, Arnaud, Babar, Amir K, Miller, Jeanette LC, Philippou, Helen, Hughes, Craig E, Herr, Andrew B, Ariëns, Robert AS, Mezzano, Diego, Jandrot-Perrus, Martine, Gachet, Christian, Watson, Steve P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927996/
https://ncbi.nlm.nih.gov/pubmed/29472360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.182972
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